Method of use of radicicol for treatment of immunopathological d

Details Method of use of radicicol for treatment of immunopathological d Method of use of radicicol for treatment of immunopathological d

1995-02-24

1998-03-24

Cintins, Marianne M.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

A61K 31335

Patent

active

057313431

ABSTRACT:
The present invention provides a method of treating an immunopathological disorder having an etiology associated with production of a proinflammatory agent, by administering a compound of the formula: ##STR1## where R1 and R2 are independently H or --COR3; R3 is H, 1-50C alkyl, 1-20C alkoxy, 2-30C alkenyl, 2-30C alkenyloxy, 2-10 alkynyl, 6-14C aryl or aryloxy, a 5-6 membered heterocycle (containing 1-3 N, O and/or S heteroatoms and optionally fused to an aryl group), 3-8C cycloalkyl (optionally fused to aryl) or 5-8C cycloalkenyl; and R4 is a halogen. Examples of such proinflammatory agents include interleukin-1 (IL-1), interleukin-6 (IL-6), interferon-.gamma. (IFN-.gamma.), tumor necrosis factor-.alpha. (TNF-.alpha.), granulocyte macrophage-colony stimulating factor (GM-CSF), the growth related gene KC, cyclooxygenase-1 (COX-1), cyclooxygenase-2 (COX-2), macrophage chemotactic protein (MCP), inducible nitric oxide synthetase (iNOS), macrophage inflammatory protein (MIP), tissue factor (TF), phosphotyrosine phosphatase (PTPase), and endotoxin.

REFERENCES:
patent: 4166764 (1979-09-01), Calton et al.
patent: 4228079 (1980-10-01), Calton
patent: 4707492 (1987-11-01), Myers-Keith et al.
Kown et al, Chemical Abstracts, vol. 118, No. 11, abstract No. 93893m, 1993, p. 28.

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