Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1995-04-28
1998-03-24
Spivack, Phyllis G.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
A61K 31415
Patent
active
057313393
ABSTRACT:
Improved methods for modulating the human sexual response by orally administering a rapidly dissolving tablet comprising phentolamine mesylate or phentolamine hydrochloride is disclosed.
REFERENCES:
patent: 3943246 (1976-03-01), Sturmer
patent: 4127118 (1978-11-01), Latorre
patent: 4139617 (1979-02-01), Grunwell et al.
patent: 4530920 (1985-07-01), Nestor et al.
patent: 4801587 (1989-01-01), Voss et al.
patent: 4863911 (1989-09-01), Anderson, Jr. et al.
patent: 4885173 (1989-12-01), Stanley et al.
patent: 5059603 (1991-10-01), Rubin
patent: 5065744 (1991-11-01), Zusmanovsky
patent: 5079018 (1992-01-01), Ecanow
patent: 5145852 (1992-09-01), Virag
patent: 5236904 (1993-08-01), Gerstenberg
patent: 5256652 (1993-10-01), El-Rashidy
patent: 5270323 (1993-12-01), Milne, Jr. et al.
patent: 5565466 (1996-10-01), Gioco et al.
Zorgniotti, International Journal of Impotence Research 6(1) 37-41 (1994 March).
AC-Di-Sol.RTM., Croscarmellose Sodium; NF (Accelerates DisSolution) (Product Description Brochure); FMC Corporation, Philadelphia, PA (1988).
Althof et al., Sexual, psychological, and marital impact of self-injection of papaverine and phentolamine: a long-term prospective study, J. Sex & Marital Ther., 17(2):101-112 (1991).
Azadzoi et al., Effects of Intracavernosal Trazadone Hydrochloride: Animal and Human Studies, J. Urol., 144(5):1277-1282 (1990).
Brindley, G.S., Cavernosal Alpha-Blockade: A New Technique for Investigating and Treating Erectile Impotence, Brit. J. Psychiat., 143:332-337 (1983).
Brindley, G.S., Cavernosal alpha-blockade and human penile erection, J. Physiol., 342:24P (1983).
Brindley, G.S., Pilot experiments on the actions of drugs injected into the human corpus cavernosum penis, Br. J. Pharmac., 87:495-500 (1986).
Corriere, Jr. et al., Development of Fibrotic Penile Lesions Secondary to the Intracorporeal Injection of Vasoactive Agents, J. Urol., 140:615-617 (1988).
Gwinup, G., Oral Phentolamine in Nonspecific Erectile Insufficiency, Ann. Int. Med., 15 Jul. 1988, 162-163.
Larsen et al., Fibrosis of Corpus Cavernosum after Intracavernous Injection of Phentolamine/Papaverine, J. Urol., 137:292-293 (1987).
Sonda et al., The Role of Yohimbine for the Treatment Of Erectile Impotence, J. Sex & Marital Ther., 16(1):15-21 (1990).
Virag, R., Intracavernous Injection of Papaverine for Erectile Failure, Lancet, ii:938 (1982).
Virag et al., Intracavernous Injection of Papaverine as a Diagnostic and Therapeutic Method in Erectile Failure, Angiology, 35:79-87 (1984).
Zorgniotti et al., Auto-Injection of the Corpus Cavernosum with a Vasoactive Drug Combination for Vasculogenic Impotence, J. Urol., 133:39-41 (1985).
Barnett and Fowler, "The Action of Regitine in Man With Special Reference To Its Adrenergic Blocking Action," pp. 109-119 (1952).
Dawson et al., "The Transient Anti-Hypertensive Effect of Phentolamine in Patients Receiving Beta-Blocker Treatment," J. Int. Med. Res., 5:462-464 (1977).
Diedrichs et al., "Reduction of Sympathetic Influence on Penile Erection by Phentolamine," Ural. Int., 46:64-66 (1991).
Georgopoulos et al., "Treatment of Chronic Heart Failure with Slow Release Phentolamine," Europ. J. Clin. Pharmacol., 13:325-329 (1978).
Godbillion and Carnis, "Determination of the Major Metabolite of Phenotolamine In Human Plasma and Urine By High-Performance Liquid Chromatography," J. Chrom., 222:461-466 (1981).
Gould et al., "Oral Therapy with Phentolamine in Chronic Congestive Heart Failure," Chest, 75(4):487-491 (Apr. 4, 1979).
Imhof et al., "Human Pharmacology of Orally Administered Phentolamine," In: Phentolamine in Heart Failure and Other Cardiac Disorders, Taylor, S. H., and Gould, L.A., (ed.), Bern Huber, pp. 11-22 (1976).
Marriott, H.J.L., "An Alarming Pressore Reactin To Regitine," 46(5):1001-1002 (May, 1957).
Montorsi et al., "Clinical Reliability of Multi-Drug Intracavernous Vasoactive Pharmacotherapy for Diabetic Impotence," Acta Diabetol, 31:1-5 (1994).
Pfister and Imhof, "Estimation of the Plasma Concentration and Course of Action of Phentol-Amine Based On its Inhibitory Effect On Adrenaline-Induced Platelet Aggregation," Br. J. Clin. Pharmac., 5:175-180 (1978).
Physicians' Desk Reference, 37 Edition, pp. 409 and 864 (1983) .
Ruskin et al., "Primary Pulmonary Hypertension Treated with Oral Phentolamine," Ann. Int. Med., 90:772-774 (1979).
Schreiber et al., "Hemodynamic Improvement Following a Single Dose of Oral Phentolamine: Administration in Patients with Chronic Low Output Cardiac Failure," Chest, 76(5):571-575 (Nov, 1979).
Selvaag and Riiser, "Experiences with Regitin (A New Vasodilator Compound.)," Acta Med. Scand., vol. CXLVI, fase. III, p. 209 (1953).
Sioufi et al., "Gas Chromatographic Determination of Phentolamine (Regitine.RTM.) In Human Plasma and Urine," J. Chrom., 222:429-435 (1981).
The Extra Pharmacopoeia, The Authoritative Reference Work On Drugs and Medicines In Current Use, Twenty-sixth Edition, 2 pages, 1988.
Trapold et al., "Pharmacological and Toxicological Studies On 2-(N-p'tolyl-N-(m'-Hydroxypheyl)-Aminomethyl)-Imidazoline (C-7337), A New Adrenergic Blocking Agent," pp. 119-126, 1950.
United Stats Pharmacopeial Convention, Inc., Rockville, Maryland, The United States Pharmacopeia, Twentieth Revision, Official from Jul. 1, 1980, The National Formulary, Fifteenth Edition, Official from Jul. 1, 1980, 615-617 (1979).
Wagner et al., "Buccal Phentolamine-A Pilot Trial For Male Erectile Dysfunction at Three Separate Clinics," Int. J. Impotence Res., 6(Suppl. 1):D78 (1994).
Williams, Textbook of Endocrinology, p. 313 (Circa, 1976).
McDonnell et al., "Imipramine-induced Erection, Masturbation, and Ejaculation in Male Horses," Pharmacol. Biochem. Behav. (USA), 27(1):187-191 (May, 1987) (ABSTRACT).
Zorgniotti, A.W., "On Demand" Oral Drug For Erection In Impotent Men, J. Urology (AUA Eighty-Seventh Annual Meeting May 10-14, 1992), 147(4)(Suppl.):308A (Apr., 1992) (ABSTRACT 382).
Spivack Phyllis G.
Zonagen, Inc.
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