Method for treating cancer using taxoid onium salt prodrugs

Details Method for treating cancer using taxoid onium salt prodrugs Method for treating cancer using taxoid onium salt prodrugs

1995-10-27

1998-03-24

Trinh, Ba K.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514449, 5462817, 549510, 549511, A61K 3144, A61K 31335, C07D40512, C07D30514

Patent

active

057313342

ABSTRACT:
C-2'-methylpyridinium acetates (MPA)-taxol and C-2'-methylpyridinium acetates (MPA)-taxotere are prodrugs having good aqueous solubility, low toxiticity and high anti-minor activity. These prodrugs are administered to patients for treating minors. Adminstration may be by injection or infusion.

REFERENCES:
patent: 4942184 (1990-07-01), Haugwitz et al.
patent: 4960790 (1990-10-01), Stella et al.
patent: 5422364 (1995-06-01), Nicolaou et al.
Swindell et al., J. Med. Chem. '91, 34, 1176-1184.
Zhao et al., J. of Natural Prod. 1991, 54, 1607-1611.
Mathew et al., J. Med. Chem. 1992, 35, 145-151.
Nicolaou et al. Nature, 1993, 364, 464-466.
Longnecker et al., Cancer Treat. Rep., 1987, 71, 53-59.
Mukaiyama, Angew. Chemie, 1979, 18, 707-808.
Nicolaou, J Chem Comm, 1993, 1024-1025.
Nicolaou et al., J. Chem. Soc., 116, 1994, 1591.
Nicolaou et al., Angew. Chem, 1994, 33, 1583.
Nicolaou et al., Angew Chem, 1994, 33, 1581-1583.
Paloma et al., Chem and Biol. 1, 1994, 107-112.
Nicolaou et al., New Perspectives in Drug Design, Acad. Press, 1995, 69.
Nicolaou et al., J.Chem Comm. 1992, 1117-1118.
Nicolaou et al., J. Chem Comm. 1992, 1118-1120.
Nicolaou et al., Nature 1994, 367, 630-634.
Nicolaou et al., J. Chem Comm. 1994, 295-296.
Nicolaou et al., J. Am. Chem. Soc. 1995, 117,624-633.
Nicolaou et al., J. Am. Chem. Soc 1995, 117, 634-644.
Nicolaou et al., J. Am. Chem. Soc 1995, 117, 645-652.
Nicolaou et al., J. Am. Chem. Soc 1995, 117, 653-659.
Deutsh et al., J. Med. Chem, 1989, 32, 788-792.

Affiliated with

Also associated with

Rating

Method for treating cancer using taxoid onium salt prodrugs does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Method for treating cancer using taxoid onium salt prodrugs, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Method for treating cancer using taxoid onium salt prodrugs will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-2289242