Methods of inhibiting plasminogen activator inhibitor 1

Details Methods of inhibiting plasminogen activator inhibitor 1 Methods of inhibiting plasminogen activator inhibitor 1

1996-09-04

1998-03-24

Lambkin, Deborah

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514422, 514212, A61K 31445, A61K 3140, A61K 3155

Patent

active

057313288

ABSTRACT:
A method of inhibiting plasminogen activator inhibitor 1 comprising administering to a human in need thereof an effective amount of a compound having the formula ##STR1## wherein R.sup.1 and R.sup.3 are independently hydrogen, --CH.sub.3, ##STR2## wherein Ar is optionally substituted phenyl; R.sup.2 is selected from the group consisting of pyrrolidine, hexamethyleneimino, and piperidino; or a pharmaceutically acceptable salt of solvate thereof.

REFERENCES:
patent: 4418068 (1983-11-01), Jones
Uchiumi et al., "Counteraction of estradiol-induced activation of tissue-type cell line plasminogen activator in a human breast cancer line by an anti-estrogen LY117018", Int. J. Cancer, vol. 47, No. 1, 1991 (pp. 80-85).
Dickerman et al., "Estrogen Regulation of Human Breast Cancer Cell Line MCF-7 Tissue Plasminogen Activator", Endocrinology, No. 125, 1989 (pp. 492-500).
Juhan-Vague et al., Annales de Biologie Clinique, (1987) 45 (2) 202-6.

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