Substituted heteroalkyleneamine neurokinin antagonists

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...

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5142355, 5142358, 514252, 514255, 514315, 514316, 514318, 514320, 514329, 514341, 514342, 514343, 544 581, 544 59, 544162, 544358, 544360, 544382, 544386, 546193, 546194, 546195, 546196, 546197, 546198, 546199, 546200, C07D40302, C07D40102, A61K 31535, A61K 3154

Patent

active

057313091

ABSTRACT:
Compounds of formula I ##STR1## wherein Q.sup.1, Q.sup.2, Q.sup.3, and Q.sup.4 have any of the meanings given in the specification, their N-oxides, and their pharmaceutically acceptable salts are nonpeptide antagonists of SP and NKA are useful for the treatment of asthma, etc. Also disclosed are pharmaceutical compositions, processes for preparing the compounds of formula I and intermediates.

REFERENCES:
Edmonds-Alt et al., Bioorg. Med. Chem. Lett, 3(5) 425-430, 1993.

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