Esculetin derivatives, method for manufacture thereof, and pharm

Details Esculetin derivatives, method for manufacture thereof, and pharm Esculetin derivatives, method for manufacture thereof, and pharm

1995-12-28

1998-03-24

Peselev, Elli

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Carbohydrate doai

514 23, 514 25, 5142375, 514451, 514457, 536 172, 536 179, 536 181, 536 53, 544151, 549269, 549273, 549289, 549294, A61K 3170, A61K 3135, C07H 1524, C07D31306

Patent

active

057312931

ABSTRACT:
A compound of the formula (I): ##STR1## wherein R.sup.1 and R.sup.2 are, independently, --CON(R.sup.4)R.sup.5, or a monosaccharide, or acylated monosaccharide group, with the proviso that at least one of R.sup.1 and R.sup.2 is --CON(R.sup.4)R.sup.5, and R.sup.4 and R.sup.5 are, independently, a hydrogen atom, or a hydroxyl, alkyl, aryl, or aralkyl group, or R.sup.4 and R.sup.5 together with the nitrogen atom attached thereto form a 3- to 7-membered saturated cycloaliphatic amino group, and R.sup.3 is a hydrogen atom, or a hydroxyl, alkyl, aryl, aralkyl, or --COOR.sup.8 group, and R.sup.3 is at 3- or 4-position, and R.sup.8 is a hydrogen atom or an alkyl group, or a salt thereof is disclosed. The compound has a function to inhibit a matrix metalloproteinase.

REFERENCES:
Chemical Abstracts, vol. 83, No. 27, 1975, Abstract #193007c, "Potential anticancer agents. IX. Synthesis of new urethane type nitrogen mustards from benzo-and naphthopyrans." Dragota et al.

Affiliated with

Also associated with

Rating

Esculetin derivatives, method for manufacture thereof, and pharm does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Esculetin derivatives, method for manufacture thereof, and pharm, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Esculetin derivatives, method for manufacture thereof, and pharm will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-2288985