Process of producing a 2-(4-alkylphenyl)-propionic acid

Details Process of producing a 2-(4-alkylphenyl)-propionic acid Process of producing a 2-(4-alkylphenyl)-propionic acid

1974-01-25

1976-06-22

Sutto, Anton H.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

260515R, 260599, 424308, C07C 6352, C07C 5124

Patent

active

039651614

ABSTRACT:
A new process of producing a 2-(4-alkylphenyl)-propionic acid known as a valuable anti-inflammatory agent is now provided, which comprises treating an alkyl 3-methyl-3-(4-alkylphenyl)-glycidate with an acid to produce 2-(4-alkylphenyl)-propionaldehyde and 3-methyl-3-(4-alkylphenyl)-pyruvic acid through a new reaction, and then oxidising these intermediate products to the desired 2-(4-alkylphenyl)-propionic acid. This new process is operable in a facile way, gives a high yield of the desired product and is suitable for a commercial practice.

REFERENCES:
patent: 3435075 (1969-03-01), Glamkowski et al.
Shiner et al., J. Am. Chem. Soc., 84 4824 (1962).
Ghosal, C.A. 64 8525f, (1969).
March, Advanced Organic Chemistry, McGraw Hill Book Co., (1968), p. 309.
Ex parte Jama, 18 J.P.O.S. 654-655.

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