Chemistry of carbon compounds – Miscellaneous organic carbon compounds – C-metal
Patent
1974-06-24
1976-06-22
Hines, Robert V.
Chemistry of carbon compounds
Miscellaneous organic carbon compounds
C-metal
26023955R, 2602472A, 2602477V, 260268C, 26029356, 260307H, 26032633, 2603265R, 260338, 2603407, 2603409, 2603459, 2603973, 2603974, 260456R, 260464, 2604651, 260468G, 260471R, 260473F, 260476C, 260485L, 260487, 260557B, 260503, 260514G, 260544L, 260544F, 260586F, 260488B, C07C10319
Patent
active
039651177
ABSTRACT:
Total synthesis of known progestationally active steroidal materials. The steroids can be synthesized depending on the particular starting reactants selected by employing as intermediates bicyclic compounds of the formula ##SPC1##
Wherein m is an integer having a value of 1 or 2; R.sub.4 is hydrogen or lower alkyl; Z is lower alkylenedioxy, CH(OR.sub.2) and carbonyl; R.sub.8 when taken alone is hydrogen; R.sub.9 when taken alone is lower alkoxycarbonyl, aryloxy-carbonyl, lower cycloalkyloxycarbonyl, carbonyl-halide, hydrogen, carboxy, formyl and methylene-X, where X is a leaving group and when taken together are methylene; with the proviso that when Z is carbonyl R.sub.8 when taken alone is hydrogen; R.sub.8 when taken alone is carbonyl halide, hydrogen, carboxy, formyl and methylene-X where X is a leaving group and when taken together are methylene and R.sub.2 is hydrogen, lower alkyl, lower alkoxy-lower alkyl, phenyl-lower alkyl, tetrahydropyranyl, lower alkanoyl, benzoyl, nitrobenzoyl, carboxy-lower alkanoyl, carboxybenzoyl, trifluoroacetyl and camphorsulfonyl.
REFERENCES:
patent: 3344169 (1967-09-01), Los
patent: 3644429 (1972-02-01), Hajos et al.
patent: 3825569 (1974-07-01), Hajos et al.
patent: 3855247 (1974-12-01), Fried
"Simple analogs of methyl steroidal hormones", El-Abbady et al., CA 67:116730a, (1967).
"Synthesis of polysubstituted cis-hydrindans", Yamamoto et al., CA 75: 110428b.
"C-acylation of 1,3-indandione . . . ", Geita et al., CA 70: 57486n, (1969).
"Attempts to prepare new aromatic systems", Baker et al., CA 43: 3399c, (1949).
Gould George M.
Hines Robert V.
Hoffmann-La Roche Inc.
Waltz Thomas A.
Welt Samuel L.
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