Triazolothienodiazepine compounds

Details Triazolothienodiazepine compounds Triazolothienodiazepine compounds

1972-10-30

1976-06-22

Rollins, Alton D.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

2602393B, 2602471L, 260268TR, 26029357, 2603322A, 2603323P, 424248, 424250, 424267, 424269, C07D49504

Patent

active

039651118

ABSTRACT:
Triazolothienodiazepine compounds of the formula; ##SPC1##
Wherein X is a member selected from the group consisting of a hydrogen atom, a methyl group, a methoxy group and a trifluoromethyl group; each of R.sup.1 and R.sup.2 is a member selected from the group consisting of a hydrogen atom and an alkyl group having 1 to 4 carbon atoms, or R.sup.1 and R.sup.2 together can form a tetramethylene group, i.e.--(CH.sub.2).sub.4 --; R is a member selected from the group consisting of a hydrogen atom, an alkyl group having 1 to 4 carbon atoms, --CONHR.sup.3 (R.sup.3 being an alkyl group having 1 to 4 carbon atoms) and -alk-N(R.sup. 4)(R.sup.5) (each of R.sup.4 and R.sup.5 being a member selected from the group consisting of a hydrogen atom and an alkyl group having 1 to 4 carbon atoms, or R.sup.4 and R.sup.5 and N can form a heterocyclic ring; and alk being an alkylene group having 2 to 4 carbon atoms); and Z is a member selected from the group consisting of an oxygen atom and a sulphur atom; and the pharmaceutically acceptable acid addition salts thereof are disclosed. These compounds are useful as minor tranquillizers (anti-anxiety drugs), sleep inducers, and anti-epileptics.

REFERENCES:
patent: 3646055 (1972-02-01), Hester
patent: 3669959 (1972-06-01), Hromatka et al.
Hester et al., J. Med. Chem., vol. 14, pp. 1078-1081, (1971).

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