Phenyl-lower-alkylamines

Details Phenyl-lower-alkylamines Phenyl-lower-alkylamines

1975-01-20

1976-06-22

Winters, Sherman D.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

260239B, 2602393R, 26029376, 2603265E, 2603268, 26032687, 2605708R, 424244, 424267, 424274, 424330, C07D21114

Patent

active

039651053

ABSTRACT:
Phenyl-lower-alkylamines having anti-inflammatory activity are prepared either by reductive alkylation of an amine with a phenyl-lower-alkanaldehyde; by condensation of a phenyl-lower-alkanaldehyde with a secondary amine, conversion of the resulting phenylvinylamine to the corresponding iminium salt, and reduction of the latter with an alkali metal borohydride; or by reaction of a phenyl-lower-alkanoyl halide with an amine and reduction of the resulting amide with a reagent effective to reduce an amide to an amine.

REFERENCES:
patent: 3573304 (1971-03-01), Eberle et al.
Arundel et al., J. Med. Chem. 9: 555 - 558 (1966).
Julia, et al., Bull. Soc. Chim. Fr. (1968) pp. 987 - 999.

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