Process for making gas-filled microspheres containing a liquid h

Details Process for making gas-filled microspheres containing a liquid h Process for making gas-filled microspheres containing a liquid h

1995-06-07

1998-03-24

Hollinden, Gary E.

Drug, bio-affecting and body treating compositions

In vivo diagnosis or in vivo testing

Ultrasound contrast agent

12866202, A61B 5055

Patent

active

057309558

ABSTRACT:
A process for making gas-filled, pressure-resistant microspheres containing a liquid or solid hydrophobic barrier within the microsphere shell.

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Ophir et al., "Contrast Agents in Diagnostic Ultrasound." Ultrasound in Med. & Biol. 15(4):319-333 (1989).
Schneider et al., "Polymeric Microballoons as Ulatrasound Contrast Agents-Physical and Ultrasonic Properties Compared with Sonicated Albumin." Inv. Radiology 27:134-139 (1992).
Wen et al., "Thermodynamics of Some Perfluorocarbon Gases in Water." J. Solution Chem. 8(3):225-246 (1979).

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