Process for the production of 1-(aminomethyl)cyclohexane acetic

Details Process for the production of 1-(aminomethyl)cyclohexane acetic Process for the production of 1-(aminomethyl)cyclohexane acetic

1990-11-15

1992-03-10

Shippen, Michael L.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carboxylic acids and salts thereof

C07C 6108

Patent

active

050951483

ABSTRACT:
A new process is described for the production of 1-(aminomethyl) cyclohexane acetic acid, a pharmaceutical agent used as an anticonvulsant. For this purpose a (1-cyanocyclohexyl)malonic acid dialkyl ester is decarbalkoxylated to the corresponding (1-cyanocyclohexyl) acetic acid alkyl ester, then transesterified with a benzyl alcohol and finally hydrogenated to form the end product.

REFERENCES:
patent: 4024175 (1977-05-01), Satzinger et al.
patent: 4152326 (1979-05-01), Hartenstein et al.
Krapcho et al., Synthesis, (1982), pp. 805-821.
New et al., Synthesis, (1983), pp. 388-389.

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