Renin inhibitors

Details Renin inhibitors Renin inhibitors

1990-11-16

1992-03-10

Ivy, C. Warren

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

546 99, 546113, 548231, 548308, 548321, 548336, 548453, 548472, 548477, 548550, C07D48704

Patent

active

050951190

ABSTRACT:
A compound of the formula: ##STR1## wherein A is ##STR2## in which X is .dbd.CH-- or .dbd.N--; R.sup.2 is hydrogen, alkyl, phenyl, benzyl or phenethyl; Y is --CH.sub.2--, --NH-- or --O--; and Z is --H.sub.2 or .dbd.O; B is His, Leu, Ile, Nva, Nle, Ala or Val; and R.sup.1 is hydrogen, alkyl, phenyl or phenylalkyl; or a pharmaceutically acceptable salt thereof are renin inhibitors.

REFERENCES:
patent: 4531964 (1985-07-01), Shimano et al.

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