Preparation of riboflavin 5'-phosphate (FMN) and its sodium salt

Details Preparation of riboflavin 5'-phosphate (FMN) and its sodium salt Preparation of riboflavin 5'-phosphate (FMN) and its sodium salt

1990-08-23

1992-03-10

Rizzo, Nicholas S.

Organic compounds -- part of the class 532-570 series

Organic compounds

Four or more ring nitrogens in the bicyclo ring system

544251, C07F 96561

Patent

active

050951157

ABSTRACT:
An improved process for preparing riboflavin 5'-phosphate (FMN) or its monosodium salt by reacting riboflavin with excess phosphorus oxychloride in a solvent, hydrolyzing of the resulting reaction mixture and, if desired, partially neutralizing with aqueous sodium hydroxide solution, comprises reacting the riboflavin with from 1.2 to 3 moles of phosphorus oxychloride per mole of riboflavin in a suitable lactone, especially .gamma.-butyrolactone, as solvent. The process is particularly advantageous when the reaction mixture is hydrolyzed at from 80.degree. to 90.degree. C. continuously or batchwise.

REFERENCES:
patent: 2111491 (1938-03-01), Kuhn et al.
patent: 2610176 (1952-09-01), Flexser et al.
patent: 2610177 (1952-09-01), Flexser et al.
patent: 4987229 (1991-01-01), Dobler et al.
Abstract for JP 008836 (3/14/72).
Derwent Abstract for JP008554 (3/11/72).
Derwent Abstract for JP008836 (3/14/72).
Tanaka et al, Chemical Abstracts, vol. 79, No. 146560 (1973).
Chemical Engineering, pp. 120-121 (Nov. 1954).
Kumagai et al, Chemical Abstracts, vol. 83, Nos. 79549-79551 (1975).
Abstract for JP 008554 (3/11/72).

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