Use of chymotrypsin for the inactivation of prekallikrein activa

Details Use of chymotrypsin for the inactivation of prekallikrein activa Use of chymotrypsin for the inactivation of prekallikrein activa

1989-02-24

1992-03-10

Stone, Jacqueline

Chemistry: molecular biology and microbiology

Carrier-bound or immobilized enzyme or microbial cell;...

435177, 435178, 435269, 424 858, 5303905, 530831, C12N 1110, C07K 1710, C07K 320, C07K 1500

Patent

active

050949497

ABSTRACT:
In order to avoid the risk of undesired side reactions of blood products, the latter are produced from plasma by using chymotrypsin to inactivate prekallikrein activator. These preparations are obtained by the fractionated enrichment of plasma proteins, with the proviso that a chymotrypsin solution or immobilized chymotrypsin is added to the fractions at any stage of the fractionation process. Before completion of the preparations, the chymotrypsin or the immobilized trypsin is removed from the preparations.

REFERENCES:
patent: 4251510 (1981-02-01), Tankersley
patent: 4272521 (1981-06-01), Zuffi
patent: 4312949 (1982-01-01), Ahrens
patent: 4608253 (1986-08-01), Ohnishi et al.
patent: 4608254 (1986-08-01), Philapitsch et al.
patent: 4814277 (1989-03-01), Eibl et al.
patent: 4886758 (1989-12-01), Eibl et al.
B. M. Alving et al., The New England Journal of Medicine, vol. 299, p. 66 (1978).

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