Stereospecific production of 6- or 7-carbon-substituted-.beta.-l

Details Stereospecific production of 6- or 7-carbon-substituted-.beta.-l Stereospecific production of 6- or 7-carbon-substituted-.beta.-l

1979-04-19

1980-12-02

Trousof, Natalie

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

2602391, 544 16, 544 17, 544 18, 544 20, 544 24, 544 27, 544 30, 548178, C07D49900, C07D50102

Patent

active

042370515

ABSTRACT:
Reaction of 6- or 7-diazo-.beta.-lactams with allylic halides in the presence of a catalytic amount of metallic copper or a copper salt affords 6- or 7-carbon-substituted-.beta.-lactams with the desired stereochemical configuration at the 6- or 7-position. Subsequent reduction with a trialkyl stannane affords useful intermediates for further syntheses affording 6- or 7-carbon-substituted-.beta.-lactams.

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