Anti-inflammatory phenyl-lower-alkylamines

Details Anti-inflammatory phenyl-lower-alkylamines Anti-inflammatory phenyl-lower-alkylamines

1975-12-17

1978-01-17

Hines, Robert V.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

260268R, 260268C, 26029355, 26029378, 26029387, 26032613R, 260442, 260456P, 26050118, 26050119, 260566A, 260599, 42424857, 424250, 424267, 424274, 424316, 424330, 544 3, 544 63, C07C 8728

Patent

active

040692566

ABSTRACT:
N-{3-[R.sub.1 -(phenyl)-C(=X)]-phenyl-lower-alkyl}amines having anti-inflammatory utility are prepared either by reduction of a 3-[R.sub.1 -(phenyl)-CO]-phenyl-lower-alkanoylamine; by benzoylating a phenyl-lower-alkylamine; by reaction of a 3-lithiophenyl-lower-alkylamine with a R.sub.1 -(phenyl)-carboxaldehyde, a R.sub.1 -(phenyl)lower-alkyl ketone or a R.sub.1 -(phenyl)-carbonitrile or by transformations involving manipulations of a carbonyl or carbinol group.

REFERENCES:
patent: 2827460 (1958-03-01), Stein et al.
patent: 2894033 (1959-07-01), Jansson et al.
patent: 2989533 (1961-06-01), Stein et al.
Burger, "Medicinal Chemistry", 2nd Ed., pp. 82-83, (1960).

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