Acylated Insulin Analogs

Details Acylated Insulin Analogs Acylated Insulin Analogs

1997-11-26

1999-07-13

Tsang, Cecilia J.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

514 3, 530304, 530303, A61K 3828, C07K 1462

Patent

active

059226757

ABSTRACT:
The present invention relates to the field of diabetes. More particularly, the invention relates to a monomeric insulin analog wherein the A chain is the naturally occurring sequence of the human insulin A chain and the B chain is modified at either position B28 and B29 or both. The analog is mono-acylated at the N-terminal of the A chain or B chain or at the lysine. The acylated insulin analogs have an extended duration of action.

REFERENCES:
patent: 3823125 (1974-07-01), Grant et al.
patent: 3864325 (1975-02-01), Smyth
patent: 3868356 (1975-02-01), Smyth
patent: 3868357 (1975-02-01), Smyth et al.
patent: 3896437 (1975-07-01), Lindsay et al.
patent: 3950517 (1976-04-01), Lindsay et al.
patent: 5474978 (1995-12-01), Bakaysa et al.
patent: 5693609 (1997-12-01), Baker et al.
Hashimoto, et al, Pharmaceutical Research, 6:2, 171-176, (1989).
Scheider, Journal of Physical Chemistry, 84:8, 925-928, (1980).
Geiger, et al., Biological Activity of Insulin Analogues Substituted at the Amino Group of B1-Phenylalanine, from Proceedings of the Second International Insulin Symposium, Aachen, Germany, Sep. 4-7, 409-415, (1979).
R. Geiger and R. Obermeier, Contribution of peptide chemistry to our knowledge of insulin and diabetes, from Proceedings of the Symposium on Proinsulin, Insulin and C-Peptide, Tokushima, 12-14 July, 62-72, (1978).
Rosen, et al, A1-Modified Insulins: Receptor Binding and Biological Activity, from Proceedings of the Second International Insulin Symposium, Aachen, Germany, Sep. 4-7. 403-408, (1979).
D.G. Lindsay and S. Shall, Biochem. J., 115, 587-595, (1969).
Muranishi, et al., Journal of Controlled Release, 19,179-188, (1992).
Hashizume, et al., J. Pharm. Pharmacol., 44 555-559, (1992).
D.L. Lindsay and S. Shall, Biochem. J., 121, 737-745, (1971).
Lapidot, et al., Journal of Lipid Research, , 8, 142-145, (1967).
Anderson, et al., Journal of American Chemical Society, 86, 1839-1842, (1964).
Asada, et al., Pharmaceutical Research, 11:8, 1115-1120, (1994).
Inoue, et al., Biochemistry, 28:16, 6619-6624, (1989).
Kunitomo, et al., The Journal of Biological Chemistry, 267:13, 8732-8738, (1992).
F.A. Carey, Organic Chemistry, McGraw Hill (N.Y.), 1110-1113, (1987).
Brems, et al., "Altering the Association of Properties of Insulin by Amino Acid Replacement", Protein Engineering, 5:6, 527-533, (1992).

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