Intermediates for aminoglycoside antibiotics

Details Intermediates for aminoglycoside antibiotics Intermediates for aminoglycoside antibiotics

1977-11-14

1979-07-03

Brown, Johnnie R.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

536 17R, 424180, C07H 1522, C07G 1100

Patent

active

041600827

ABSTRACT:
Derivatives of kanamycin A, which have an acyl protecting group on the C-3" and C-6' amino groups, and optionally have a benzyl protecting group on the C-3 amino group, are useful intermediates for the preparation of 1-N-(.omega.-amino-2-hydroxyalkyl) derivatives of kanamycin A. Derivatives of kanamycin B, which have an acyl protecting group on the C-2', C-3" and C-6' amino groups, and optionally have a benzyl protecting group on the C-3 amino group, are useful intermediates for the preparation of 1-N-(.omega.-amino-2-hydroxyalkyl) derivatives of kanamycin B. Certain of the partially protected kanamycin A and kanamycin B derivatives of this invention are useful for preparing 1-N-(.omega.-amino-2-hydroxyalkanoyl) derivatives of kanamycin A and B. 1-N-(.omega.-Amino-2-hydroxyalkyl) and 1-N-(.omega.-amino-2-hydroxyalkanoyl)derivatives of kanamycin A and B are known antibacterial agents.

REFERENCES:
patent: 3781268 (1973-12-01), Kawaguchi et al.
patent: 3904597 (1975-09-01), Naito et al.
patent: 4001208 (1977-01-01), Umezawa et al.
patent: 4065615 (1977-12-01), Horii et al.

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