Peptides and process for their manufacture

Details Peptides and process for their manufacture Peptides and process for their manufacture

1977-10-04

1979-07-03

Phillips, Delbert R.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

C07C10352

Patent

active

041599810

ABSTRACT:
The new hypocalcaemically active peptides of formula I ##STR1## and corresponding compounds in which one or more of the asparagine and glutamic acid radicals are replaced by the aspartic acid or glutamic acid radical and/or the aspartic acid radical is replaced by the asparagine radical, their dimers, especially those in which 2 identical peptide sequences (1-32 and 1'-32') are joined in an anti-parallel arrangement via the cysteine radicals 1,7' and 7,1' by means of a disulfide bond, and derivatives are useful as hypocalcaemic agents and are prepared by splitting off groups protecting at least one amino or one carboxyl group or oxidizing the corresponding sulfides to the disulfides or condensing together adequate peptides.

REFERENCES:
patent: 3934008 (1976-01-01), Rittel et al.
Kumar et al., J. Endocrin. (1965) pp. 469-475.
Chem. Ber., 100, 3838-3840 (1967).
Chem. Ber., 101, 681-693 (1968).
Barrett et al., J. Clin. Endocrinl Metab. 28, 734-739 (1968).
Neber, et al., Helv. Chim. Acta 51, 1900-1905, 1968.
Sieber, et al., Helv. Chim. Acta 51, 2057-2061(1968).
Weygand, et al., Chem. Ber. 100, 3838-3840 (1967).
Konig, et al., Chem. Ber. 101, 681-693 (1968).

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