Protected amino acids or peptides

Details Protected amino acids or peptides Protected amino acids or peptides

1978-04-18

1979-07-03

Phillips, Delbert R.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

562430, C07C10352

Patent

active

041599799

ABSTRACT:
In an amino acid having .omega.-amino group protected with a protective group or a peptide having the residue of such a protected amino acid, the improvement according to which the protective group is p-methylbenzylsulfonyl group. The .omega.-amino acids protected with p-methylbenzylsulfonyl or the peptides having residues of such protected amino acids are useful for production of various peptides by liquid phase method as well as by solid-phase method, because the protective group has specific selectivity of remaining stable under the conditions commonly employed in the removal of .alpha.-aminoprotecting group but is cleaved smoothly in a good yield by hydrogen fluoride without exerting untoward unfluences upon peptides.

REFERENCES:
patent: 3131174 (1964-04-01), Schwyzer
patent: 3926938 (1975-12-01), Hughes et al.
patent: 3928306 (1975-12-01), Uchiyama et al.
D. Chung, et al., J. Am. Chem. Soc. 89, 1967, pp. 4208-4213.

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