Physiologically active substance, arphamenine and production the

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Radical -xh acid – or anhydride – acid halide or salt thereof...

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562439, A61K 31195, C07C11900

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active

045956987

ABSTRACT:
New physiologically active substances, arphamenine A and arphamenine B which are generically termed arphamenine are produced from a new microorganism, BMG361-CF4 strain identified as FERM P-6521 or FERM BP-286 or ATCC No. 39373. Arphamenine is useful as a host defence stimulator having an activity to enhance cell-mediated immunity, and also as an anti-tumor agent.

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patent: 4105789 (1978-08-01), Ondetti et al.
Umezawa et al., Chemical Abstracts, vol. 100, No. 175262, (1983).
Miller et al., J. Nat. Conc. Soc., vol. 51, No. 5, pp. 1669-1675, Nov. 1973.
Lagrange et al, J. Exptl. Med., vol. 139, pp. 1529-1539; 528-542, 1974.

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