Antihypertensive 2-amino-4,5-dihydropyridine derivatives

Details Antihypertensive 2-amino-4,5-dihydropyridine derivatives Antihypertensive 2-amino-4,5-dihydropyridine derivatives

1974-10-29

1979-01-23

Schenkman, Leonard

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Parasitic organism or component thereof or substance...

424246, 42424854, 42424855, 424250, A61K 31455

Patent

active

041361873

ABSTRACT:
4,5-Dihydropyridines bearing an N,N-disubstituted amino group in the 2-position, carbonyl functions in the 3- and 5-positions and being optionally substituted in the 6-position by lower alkyl or phenyl and, in the 4-position by lower alkyl, phenyl, substituted phenyl or a heterocyclic group, are antihypertensive agents and coronary vessel dilators. The compounds, of which 2-pyrrolidino-6-methyl-4-(3-nitrophenyl)-4,5-dihydropyridine-3,5-dicarboxy lic acid 3,5-diethyl ester is a representative embodiment, are prepared through condensation of an ylideneacetoacetic acid ester and a substituted 3,3-diaminoacrylate.

REFERENCES:
patent: 3441648 (1969-04-01), Loev et al.
patent: 3485847 (1969-12-01), Bossert et al.
patent: 3488359 (1970-01-01), Bossert et al.
patent: 3708489 (1973-01-01), Rucker et al.
patent: 3773773 (1973-11-01), Bossert

Affiliated with

Also associated with

Rating

Antihypertensive 2-amino-4,5-dihydropyridine derivatives does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Antihypertensive 2-amino-4,5-dihydropyridine derivatives, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Antihypertensive 2-amino-4,5-dihydropyridine derivatives will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-2273442