Cocaine derivatives

Details Cocaine derivatives Cocaine derivatives

1991-12-16

1993-08-03

Raymond, Richard L.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

546130, 546131, C07D45106, C07D45110

Patent

active

052330427

ABSTRACT:
Compounds are provided for the preparation of reagents, including labels which can be used in immunoassays of cocaine and cocaine metabolites. The compounds are derivatives of cocaine which are conjugated to antigenic proteins or polypeptides for the formation of antibodies for use in immunoassays. The compounds also may be conjugated to labels for use in immunoassays.

REFERENCES:
patent: 3888866 (1975-06-01), Leute et al.
patent: 4102979 (1978-07-01), Christenson
patent: 4123431 (1978-10-01), Soffer et al.
Ambre, John J., et al., A Kinetic Model of Benzolecgonine Disposition After Cocaine Administration in Humans, J. Anal. Tox. 15:17-20 (1991).
DeJong, A. W. K., Some Properties of the Ecgonines and Their Esters, Rec. Trav. Chim. 66:544-548 (1947).
Smith, R. Martin, Ethyl Esters of Arylhydroxy- and Arylhydroxymethoxycococaines in the Urines of Simultaneous Cocaine and Ethanol Users, J. Anal. Tox. 8:38-42 (1984).
Rafla, Fathi K. and Epstein, Robert L., Identification of Cocaine and its Metabolites in Human Urine in the Presence of Ethyl Alcohol, J. Anal. Tox. 3:59-63 (1979).

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