Drug – bio-affecting and body treating compositions – Radionuclide or intended radionuclide containing; adjuvant... – Molecular bilayer structure
Patent
1974-11-11
1977-04-05
Wolk, Morris O.
Drug, bio-affecting and body treating compositions
Radionuclide or intended radionuclide containing; adjuvant...
Molecular bilayer structure
23230B, 232303, 424 15, 424 12, 260112R, G01N 3316
Patent
active
040162508
ABSTRACT:
Method for the determination of the hormone human chorionic gonadotropin (HCG), luteinizing hormone (LH), prolactin (PRL) and HCG-like material in an aqueous sample comprising contacting a highly specific receptor for these hormones with an aqueous sample to be tested, providing a means of indicating whether binding has taken place between the receptor and hormone possibly contained in the sample and observing the indicating means to determine the presence of the hormone in the sample. PRL may be determined separately or simultaneously with the HCG and LH. The receptor is a plasma membrane extract from the corpus luteum of an animal which possesses the receptor for HCG, LH, PRL and HCG-like material. Radioassay indicating means are preferred, according to which competitive protein binding between radioisotopically labeled hormone and hormone present in the sample is radiologically determined. The method has particular application to the determination to pregnancy in the human female.
REFERENCES:
F. Haour et al., J. Biol. Chem., 249(7), 2195-2205 (1974).
K. M. J. Menon et al., Biochem. and Biophys. Res. Comm., 56(2) (1974).
Ch. V. Rao et al., Biochimica et Biophysica Acta, 313, 372-389 (1973).
D. S. Skelley et al., Clin. Chem., 19(2) (1973).
Barnard Ralph R.
Cornell Research Foundation Inc.
Laubscher Lawrence E.
Marantz Sidney
Wolk Morris O.
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