Process for the purification of peptides

Details Process for the purification of peptides Process for the purification of peptides

1989-04-05

1990-06-19

Brust, Joseph Paul

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

C07D20709

Patent

active

049355260

ABSTRACT:
A process for the purification and extraction of the dipeptide .epsilon.-tri-fluoroacetyllysylproline from a saturated aqueous solution of salt containing the dipeptide, at least one polypeptide and at least one isolated amino acid, by a series of successive extractions with a primary alcohol or a primary alcohol/aprotic solvent mixture.

REFERENCES:
patent: 4465626 (1984-08-01), Sklavounos
patent: 4720554 (1988-01-01), Irie et al.
Biopolymers, vol. 1, pp. 517-525 (1963).
Journal of Organic Chemistry, vol. 37, No. 2, pp. 327-329 (1972).
Synthesis of ACE Inhibitors, Peptides Funct. Proc. Am. Pept. Symp. 9th pp. 787-790 (1985).

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