Process for the preparation of hydroxyethylsulfonylnitro- and hy

Details Process for the preparation of hydroxyethylsulfonylnitro- and hy Process for the preparation of hydroxyethylsulfonylnitro- and hy

1990-08-03

1992-03-31

Dees, Jose G.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carboxylic acids and salts thereof

560 12, C07C 51367

Patent

active

051010690

ABSTRACT:
A process for the preparation of compounds of the formula (5) ##STR1## in which R denotes a hydrogen or oxygen atom and the --N(R).sub.2 group and the hydroxyethylsulfonyl group are in the ortho- or para-position relative to one another by converting 1 mol of a halonitrobenzoic acid of the formula (2) ##STR2## in which X denotes a fluorine, chlorine, bromine or iodine atom and the nitro group and the halogen atom are in the ortho- or para-position relative to one another, with at least 1 mol of mercaptoethanol in an aqueous solution or suspension or in an organic solvent in the presence of an acid-binding agent at temperatures from about 20.degree. to about 100.degree. C., to the corresponding hydroxyethylmercaptonitrobenzoic acid of the formula (3) ##STR3## oxidizing these acids in a manner known per se to the corresponding hydroxyethylsulfonylnitrobenzoic acids of the formula (5) (R=0) mentioned and reducing the latter, if necessary, in a manner known per se to the corresponding hydroxyethylsulfonylaminobenzoic acids of the general formula (4) ##STR4## in which the amino and hydroxyethylsulfonyl group are in the ortho- or para-position relative to one another.

REFERENCES:
patent: 3250764 (1966-05-01), Schmidt et al.
patent: 3729508 (1973-04-01), Ziegler et al.

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