Process for isolating basic proteins from protein mixtures

Chemistry: natural resins or derivatives; peptides or proteins; – Peptides of 3 to 100 amino acid residues – Insulin; related peptides

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530303, 530412, 530416, 530417, C07K 500, C07K 322

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active

051010135

ABSTRACT:
Basic proteins are isolated from protein mixtures which contain such basic proteins and which are obtained by enzymatic clevage of proinsulin and/or its derivatives of natural, semisynthetic or genetic engineering origin by ion exchanger chromatography on strongly acid cation exchangers.

REFERENCES:
patent: 4129560 (1978-12-01), Zoltobrocki
patent: 4644057 (1987-02-01), Bicker et al.
Wilson, Chem. Abst., 104, 84(1986) Entry No. 62218b.
D. Steiner et al., J. Biol. Chem., vol. 246, No. 5, pp. 1365-1374, (1971).
J. Markussen et al., Protein Engineering, vol. 1, No. 3, pp. 205-213 (1987).
U. Krabieli et al., Chemical Abstracts, vol. 108, No. 226915 (1988).

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