Prostaglandin analogues, process for their preparation and pharm

Details Prostaglandin analogues, process for their preparation and pharm Prostaglandin analogues, process for their preparation and pharm

1989-03-30

1990-06-19

Gerstl, Robert

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Ester doai

514573, 560118, 562500, 536 46, C07C17700, A61K 31557

Patent

active

049354469

ABSTRACT:
The present invention relates to novel isomers of PGAs, PGDs, PGEs, PGFs, 6-keto-PGE.sub.1 s, 6-keto-PGF.sub.1 s, PGI.sub.2 s, 6,9.alpha.-nitrilo-PGI.sub.1 s and 6,9.alpha.-methano-PGI.sub.2 s, having a specific steric configuration, which are replaced by an alkyl (C.sub.1 to C.sub.8)-substituted cycloalkyl (C.sub.4 to C.sub.7) group in 1S,S) form, in 1S,R) form or in cis form at the 15-, 16- or 17-position of the PG skeleton, and, alkyl esters thereof, non-toxic salts thereof, non-toxic acid addition salts thereof and cyclodextrin clathrates thereof, possessing more potent PG-like pharmacological activity than other isomers.

REFERENCES:
patent: 4180675 (1979-12-01), Hayashi
patent: 4220795 (1980-09-01), Kluendes
patent: 4275075 (1981-06-01), Kurono
patent: 4278688 (1981-07-01), Hayashi
patent: 4562207 (1985-12-01), Imaaki

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