Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Recombinant dna technique included in method of making a...
Patent
1989-01-24
1990-06-19
Wiseman, Thomas G.
Chemistry: molecular biology and microbiology
Micro-organism, tissue cell culture or enzyme using process...
Recombinant dna technique included in method of making a...
435244, 43525233, 4352536, 530351, 935 61, 935 66, 935 73, C12P 2102, C12P 2100, C12N 138, C12N 120, C07K 1300, C07K 1326
Patent
active
049353560
ABSTRACT:
The present invention provides an improvement in a method for producing interleukin-2 by cultivating a transformant of Escherichia coli capable of producing interleukin-2 into a medium, which comprises inoculating said Escherichia coli into the medium of pH from about 4.8 to 6.0 and growing it while maintaining this pH range.
By the method of the present invention, the interleukin-2 productivity is considerably improved.
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patent: 4357422 (1982-01-01), Giard et al.
patent: 4391907 (1983-07-01), Matsui et al.
patent: 4499188 (1985-02-01), Konrad et al.
patent: 4569790 (1986-02-01), Koths et al.
Queen, C. (1983) J. Mol. Appl. Genet, 2, 1-10.
Fujimoto Shigeru
Kitano Kazuaki
Conlin David G.
Linek Ernest V.
Patterson Charles L.
Takeda Chemical Industries Ltd.
Wiseman Thomas G.
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