Prevention or treatment of sunburn using the S(+) isomer of ibup

Details Prevention or treatment of sunburn using the S(+) isomer of ibup Prevention or treatment of sunburn using the S(+) isomer of ibup

1990-10-05

1992-03-31

Friedman, S. J.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Radical -xh acid, or anhydride, acid halide or salt thereof...

A61K 3119

Patent

active

051009188

ABSTRACT:
Ultraviolet radiation induced erythema is prevented or treated in a human mammal in need of such prevention or treatment, i.e., a mammal suffering from or seeking to avoid sunburn, by topically administering thereto a unit dosage erythema-preventing or treating effective amount of the S(+) ibuprofen enantiomer, said enantiomer being substantially free of its R(-) ibuprofen antipode.

REFERENCES:
S. S. Adams et al., 1975, Curr. Med. Res. Opin. 3(8):552, "The Optical Isomers of Ibuprofen".
S. S. Adams et al., 1976, J. Pharm. Pharmacol., 28:256-257, "Pharmacological Differences Between the Optical Isomers of Ibuprofen: Evidence for Metabolic Inversion of the (-)-Isomer".
T. Y. Shen, 1972, In Angewandte Chem. Internat. Ed. 11(6):460-472, "Perspectives in Nonsteroidal Anti-Inflammatory Agents".
Edwards et al., Arch. Dermatol. Res., 272:263-267, "Reduction of Erythema Response to UV Light by Nonsteroidal Anti-Inflammatory Agents".
A. J. Hutt et al., 1983, J. Pharm. Pharmacol. 35:693-704, "The Metabolic Chiral Inversion of 2-Arylpropionic Acids-A Novel Route with Pharmacological Consequences".
Lim et al., 1983, J. Invest. Dermatol. 81(5):455-458, "Effects of Indomethacin on Alterations of ATPase-Positive Langerhans Cell Density and Cutaneous Sunburn Reaction Induced by UV-B Radiation".
Snyder et al., 1974, J. Invest. Dermatol. 62(1):47-50, "Intradermal Anti-Prostaglandin Agents and Sunburn".
Snyder et al., 1974, Br. J. Dermatol. 99-91, "Topical Indomethacin and Sunburn".

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