Dihydropyridine vasodilator agents

Details Dihydropyridine vasodilator agents Dihydropyridine vasodilator agents

1990-11-13

1992-03-31

Daus, Donald G.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

514335, 544238, 546256, 546257, 546261, 546273, 548482, A61K 3150, C07D23704

Patent

active

051008920

ABSTRACT:
Compounds of the following formula (I): ##STR1## where R.sup.1 and R.sup.2 are alkyl or cycloalkyl, which may be substituted, R.sup.4 is aryl such as phenyl which may be substituted, L is a direct bond or an oxygen containing linking group, R is a hydrogen, alkyloxy, alkyl, halogen or haloalkyl and Het is a pyridinyl or pyridazinyl group. The compounds can be used antihypertensives or myocardial relaxants. Also part of the invention are pharmaceutical compositions, intermediates and methods of synthesis.

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