Preferential alkylation or acylation of meta-disubstituted benze

Details Preferential alkylation or acylation of meta-disubstituted benze Preferential alkylation or acylation of meta-disubstituted benze

1976-07-22

1977-11-22

Levine, Herbert

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

C07C 2508

Patent

active

040596427

ABSTRACT:
In a mixture of isomers of a disubstituted benzene such as dichlorobenzene, the meta-disubstituted isomer is preferentially reacted with an alkylating or acylating agent, e.g., an alkyl halide, by contacting the mixture with the agent in the presence of a Friedel-Craft catalyst at a temperature of less than about 60.degree. C.
The resulting alkylated or acylated meta-isomer can be readily separated from the reaction mixture by simple distillation.

REFERENCES:
patent: 3358046 (1967-12-01), Offenhauer et al.
Olah et al., Aromatic Substitution XVIII, Friedel-Crafts t-Butylation of Benzene and Methylbenzenes with t-Butyl Bromide and Isobutyleen; JACS; 86; 3-20-64; p. 1060.

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