Polylactic acid type microspheres containing physiologically act

Details Polylactic acid type microspheres containing physiologically act Polylactic acid type microspheres containing physiologically act

1989-02-24

1992-03-31

Lovering, Richard D.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Implant or insert

42721336, 424489, 424497, 42840224, 514963, A61K 950, B01J 1312

Patent

active

051006693

ABSTRACT:
Microspheres comprising polylactic acid and a water soluble physiologically active substance and having a mean particle size of from about 0.01 .mu.m to 300 .mu.m, which show not more than 30% of an eluted amount of said physiologically active substance based on the content of said physiologically active substance in the polylactic acid type microspheres after 24 hours in in vitro elution test in phosphate buffer of pH 7.4 at 37.degree. C., and a process for preparing the same. The polylactic acid type microspheres of this invention is advantageous in that the active substance can be uniformly incorporated into the microspheres without loss of the activity, can gradually release the active substance for a long time of period of more than one week.

REFERENCES:
patent: 4389330 (1983-06-01), Tice et al.
patent: 4479911 (1984-10-01), Fong
patent: 4492720 (1985-01-01), Mosier
patent: 4542025 (1985-09-01), Tice et al.
patent: 4622244 (1986-11-01), Lapka et al.
patent: 4637905 (1987-01-01), Gardner
patent: 4675189 (1987-06-01), Kent et al.
patent: 4832686 (1989-05-01), Anderson
patent: 4835139 (1989-05-01), Tice et al.
patent: 4849228 (1989-07-01), Yamamoto et al.
patent: 4853226 (1989-08-01), Machida et al.

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