Preparation of 2',3'-didehydro-3'-deoxythymidine from 5-methylur

Details Preparation of 2',3'-didehydro-3'-deoxythymidine from 5-methylur Preparation of 2',3'-didehydro-3'-deoxythymidine from 5-methylur

1994-09-23

1997-09-30

Kunz, Gary L.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

536 2854, C07H 100, C07H 106, C07H 19073

Patent

active

056726988

ABSTRACT:
An economical process, amenable to large-scale production, is disclosed for the preparation of 2',3'-didehydro-3'-deoxythymidine (d4T) from 5-methyluridine. The process employs a novel, 5'-,acyl-2'.alpha.-halo-3'.alpha.-alkanesulfonylthymidine intermediate as well as a highly efficient and practical deprotection, isolation and purification procedure for the d4T product.

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