Immunoglobulin F.sub.c fragment bound to an alkylating, antibiot

Details Immunoglobulin F.sub.c fragment bound to an alkylating, antibiot Immunoglobulin F.sub.c fragment bound to an alkylating, antibiot

1993-07-20

1997-09-30

Loring, Susan A.

Chemistry: natural resins or derivatives; peptides or proteins;

Proteins, i.e., more than 100 amino acid residues

Blood proteins or globulins, e.g., proteoglycans, platelet...

5303871, 5303911, 530861, 530866, C07K 1600, C07K 1618

Patent

active

056726880

ABSTRACT:
A composition comprising as an active ingredient a compound consisting of an immunoglobulin F.sub.c fragment and an alkylating, antibiotic, or antimetabolic antitumor substance bound thereto, and a pharmaceutically acceptable carrier is disclosed. The Fc fragment moiety in the compound is stable in a living body, and thus the activity of the antitumor substance therein is maintained over a long period.

REFERENCES:
patent: 4867973 (1989-09-01), Goers et al.
patent: 5091523 (1992-02-01), Talebian et al.
patent: 5200178 (1993-04-01), Strauss et al.
Capon, D.J. et al., Nature, 337:525-531, 9 Feb. 1989.
Kobayashi, A. et al., J. Bioactive & Compatible Polymers, 3:319-333, Oct. 1988.
Derwent Abstract AN 91-245698.
European Search Report No. EP 93 11 1839.
Perkins, A.C., Eur. J. Nucl Med, 19: 385-386, 1992.
Martin, D.S. et al., Cancer Res, 46: 2189-2192, Apr. 1986.
Waldmann, T.A., Science, 252: 1657-1662, Jun. 21, 1991.
Illustrated Dictionary of Immunology, ed: Cruse & Lewis, 1995, pp. 108-110.
Osband, M.E. et al, Immunology Today, 11(5): 193-195, 1990.

Affiliated with

Also associated with

Rating

Immunoglobulin F.sub.c fragment bound to an alkylating, antibiot does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Immunoglobulin F.sub.c fragment bound to an alkylating, antibiot, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Immunoglobulin F.sub.c fragment bound to an alkylating, antibiot will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-2257386