Integrin receptor antagonists

Details Integrin receptor antagonists Integrin receptor antagonists

1997-11-26

2000-10-10

Raymond, Richard L.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514 63, 514 82, 514183, 514212, 514218, 5142282, 5142352, 514255, 514256, 514269, 514272, 514274, 514275, 514300, 514303, 514307, 540487, 540492, 540542, 540553, 540597, 544 57, 544 62, 544 69, 544128, 544180, 544212, 544219, 544229, 544243, 544297, 544310, 544312, 544316, 544319, 544320, 544328, 544329, 544331, 544332, 544333, 544335, 544337, 544363, 546 14, 546 23, 546118, 546122, 546146, 546156, A61K 314709, A61K 31472, A61K 31496, A61K 315355, C07D21512, C07D40102, C07D41302, C07D41702

Patent

active

061302317

ABSTRACT:
This invention relates to novel fused heterocycles which are useful as antagonists of the .alpha..sub.v .beta..sub.3 and related integrin receptors, to pharmaceutical compositions containing such compounds, processes for preparing such compounds, and to methods of using these compounds, alone or in combination with other therapeutic agents, for the inhibition of cell adhesion, the treatment of angiogenic disorders, inflammation, bone degradation, cancer metastasis, diabetic retinopathy, thrombosis, restenosis, macular degeneration, and other conditions mediated by cell adhesion and/or cell migration and/or angiogenesis.

REFERENCES:
patent: 5622967 (1997-04-01), Dolle et al.

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