Synthetic resins or natural rubbers -- part of the class 520 ser – Synthetic resins – Mixing of two or more solid polymers; mixing of solid...
Patent
1995-10-02
1997-09-30
Krass, Frederick
Synthetic resins or natural rubbers -- part of the class 520 ser
Synthetic resins
Mixing of two or more solid polymers; mixing of solid...
525409, 525 541, 525 61, 5253268, 564475, 564477, 560198, 560200, 560230, 568 62, 568623, 568624, 568625, 556410, 556412, 548461, 548462, 562537, 562538, 424450, 4241791, 4241931, 424 941, 546208, 546243, 548435, 548465, 548475, 548520, 548542, 530402, 530404, 530405, 530406, 530408, 530409, 530410, C08G 6532, A61K 31765
Patent
active
056726627
ABSTRACT:
Active esters of PEG acids and related polymers are provided that have a single propionic or butanoic acid moiety and no other ester linkages. These polymer acids have a half life in water of from about 10 to 25 minutes. For example, alpha-methoxy, omega-propionic acid succinimidyl ester of PEG ("methoxy-PEG-SPA") has a nearly ideal reactivity with amino groups on proteins and other biologically active substances. The half life of methoxy-PEG-SPA is about 16.5 minutes in water. The invention also provides conjugates with proteins, enzymes, polypeptides, drugs, dyes, nucleosides, oligonucleotides, lipids, phospholipids, liposomes, and surfaces of solid materials that are compatible with living organisms, tissue, or fluid.
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Polymer Preprints, vol. 31, No. 2, 1990, Samuel Zalipsky et al., "Succinimidyl Carbonates of Polyethylene Glycol: Useful Reactive Polymers for Preparation of Protein Conjugates".
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Harris J. Milton
Kozlowski Antoni
Krass Frederick
Shearwater Polymers, Inc.
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