Substituted spirodienes for the treatment of inflammation

Details Substituted spirodienes for the treatment of inflammation Substituted spirodienes for the treatment of inflammation

1996-07-09

1997-09-30

Rotman, Alan L.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Ester doai

558413, 564 85, 564 89, 564 90, 568 27, 568 29, 568 32, 568 33, 568 35, 514604, 514708, 514709, 546 15, A61K 31275, C07C25549, C07C30702, C07C31714

Patent

active

056726279

ABSTRACT:
A class of substituted spirodienes is described for use in treating inflammation and inflammation-related disorders. Compounds of particular interest are defined by Formula III: ##STR1## wherein R.sup.3 is methylsulfonyl or sulfamyl; and wherein R.sup.8 is selected from hydrido, fluoro, chloro, bromo, iodo, methyl, ethyl, n-propyl, isopropyl, butyl, tert-butyl, isobutyl, methoxy, ethoxy, propoxy, butoxy, hydroxyl, mercapto, methylthio, ethylthio, cyano, fluoromethyl, difluoromethyl, trifluoromethyl, chloromethyl, dichloromethyl, trichloromethyl, pentafluoroethyl, heptafluoropropyl, difluorochloromethyl, dichlorofluoromethyl, difluoroethyl, difluoropropyl, dichloroethyl, dichloropropyl, trifluoromethoxy, hydroxymethyl, methoxymethyl and ethoxymethyl; or a pharmaceutically-acceptable salt thereof.

REFERENCES:
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H. Zimmerman and J. Pincock, J. Amer. Chem. Soc., 95, 3246 (1973).
K. Hirao et al, J. Chem. Soc., Chem. Commun., 300 (1984).
M. Hamer and Stubs, J. Chem. Soc., D, 1013 (1970).

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