Tricyclic compounds useful for inhibition of G-protein function

Details Tricyclic compounds useful for inhibition of G-protein function Tricyclic compounds useful for inhibition of G-protein function

1995-05-22

1997-09-30

McKane, Joseph

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514318, 514319, 514316, 514323, 5142278, 5142282, 5142355, 544 60, 544126, 544129, 546 89, 546 93, 546196, 546202, 546203, A61K 31445, C07D21106

Patent

active

056726112

ABSTRACT:
Novel compounds of Formula ##STR1## are disclosed. Also disclosed is a method of inhibiting Ras function and therefore inhibiting the abnormal growth of cells. The method comprises administering a compound of the Formula 1.0 to a biological system. In particular, the method inhibits the abnormal growth of cells in a mammal such as a human being.

REFERENCES:
patent: 4282233 (1981-08-01), Villani
patent: 4826853 (1989-05-01), Piwinski et al.
patent: 4831042 (1989-05-01), Villani
patent: 4863931 (1989-09-01), Schumacher et al.
patent: 5089496 (1992-02-01), Piwinski et al.
patent: 5104876 (1992-04-01), Piwinski et al.
patent: 5112817 (1992-05-01), Fukazawa et al.
patent: 5141851 (1992-08-01), Brown et al.
patent: 5151423 (1992-09-01), Piwinski et al.
Cell, 65, 1-4 (1991).
J. Biol. Chem., 266, (24) 15575-15578 (1991).
Proc. Natl. Acad. Sci. USA, 87, 3042-3046 (1990).
Proc. Natl. Acad. Sci. USA, 88, 8631-8635 (1991).
Nature, 356, 713-715 (1992).
Proc. Natl. Acad. Sci. USA, 87, 7541-7545 (1990).
J. Bio. Chem., 265, (25) 14701-14704 (1990).
Proc. Natl. Acad. Sci. USA, 87, 7926-7929 (1990).
Cell, 62, 81-88 (1990).
Biochemistry, 31, 3800-3807. (1990).
Science, 260 (1993), 1934-1937.
Science, 260 (1993), 1937-1942.
Piwinski, et al., J. Med. Chem., 34, (1) 457-461 (1991).
Chem Abstracts No. 121:53129x (1994) for WO94/04561.
Sebti, et al., Proc. Ann. Meeting AM Assoc. Cancer Res., 33:A2217 (1992).
Villani, et al., J. Med. Chem., 15, (7) 750-754 (1972).
Billah, et al., Lipids, 26, (12) 1172-1174 (1991).
Villani, et al., Arzneim.-Forsch./Drug Res., 36(II), 1311-1314 (1986).

Affiliated with

Also associated with

Rating

Tricyclic compounds useful for inhibition of G-protein function does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Tricyclic compounds useful for inhibition of G-protein function , we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Tricyclic compounds useful for inhibition of G-protein function will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-2256828