Compounds containing a fused bicycle ring

Details Compounds containing a fused bicycle ring Compounds containing a fused bicycle ring

1995-11-22

1997-09-30

Grumbling, Matthew V.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

5142302, 514 80, 514211, 5142305, 544 55, 544 92, 544 48, 544 91, 540490, 562556, 564502, 564503, 564504, 564505, C07D41302, C07D41702, A61K 31535, A61K 3154

Patent

active

056725990

ABSTRACT:
Compounds of the formula ##STR1## wherein X is O or S--(O).sub.t ; n is one; m is zero or one; Y is CH.sub.2, O, or S--(O).sub.t provided that Y is O or S--(O).sub.t only when m is one; and A is ##STR2## are dual inhibitors of NEP and ACE. Compounds wherein A is ##STR3## are selective ACE inhibitors. Also disclosed are methods of preparation and intermediates.

REFERENCES:
patent: 5362727 (1994-11-01), Robl
patent: 5504080 (1996-04-01), Karanewsky
patent: 5508272 (1996-04-01), Robl
patent: 5525723 (1996-06-01), Robl
patent: 5552397 (1996-09-01), Karanewsky et al.
Baldwin et al., J. Chem. Soc. Chem. Commun., 1993, pp. 935-936.

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