Chemistry: molecular biology and microbiology – Animal cell – per se ; composition thereof; process of...
Patent
1994-08-05
1997-09-30
Elliott, George G.
Chemistry: molecular biology and microbiology
Animal cell, per se ; composition thereof; process of...
4353201, 435 911, 536 232, C12N 510, C12N 1509, C12N 1512, C07H 2104
Patent
active
056725094
ABSTRACT:
This invention relates to a novel nucleic acid sequence encoding a novel human phosphodiesterase IV (hPDE IV) isozyme. It also relates to a polypeptide encoded by such sequence.
This invention also relates to an assay method for detecting the presence of such novel isozyme in human cells, and to a method of identifying compounds or other substances that inhibit or modify the activity of such isozyme.
REFERENCES:
patent: 5501969 (1996-03-01), Hastings et al.
patent: 5504003 (1996-04-01), Li et al.
patent: 5527896 (1996-06-01), Wigler et al.
Obernolte et al., Gene, 129, 239-247 (1993).
Kurihara et al., Biochem, Biophys. Res. Comm., 170 (3), 1074-1081 (1990).
Weishaar et al., J. Med. Chem., 28 (5), 537-545 (1985).
Giembycz, M.A., Biochem. Pharm., 43 (10) 2041-2051 (1992).
Davis et al., Proc. Nat'l. Acad. Sci. U.S.A., 83, 9313-9317 (Dec., 1986).
Conti et al., Proc. Nat'l. Acad. Sci. U.S.A., 86, 5325-5329 (Jul., 1989).
Livi et al., Mol. Cell. Biol., 10 (6), 2678-2686 (Jun., 1990).
Livi et al., J. Biol. Chem., 268 (9), 6470-6476 (Mar., 1993).
Davis et al., J. Cyclic Nucleotide Research, 5 (1), 65-74 (1979).
Frohman et al., Technique--A Journal of Methods in Cell and Molecular Biology, 1 (3), 165-170 (Dec., 1989).
Chomoczynski et al., Analytical Biochem, 162, 156-159 (1987).
Torphy et al., Mol. Pharm., 37, 206-214 (1990).
Beavo et al., TIPS Reviews, 149-155 (1990).
Beavo, J., "Cyclic Nucleotide Phosphodiesterases: Structure, Regulation and Drug Action", pp. 3-15, edited by Beavo, J. and Housley, M.D., John Wiley and Sons, Ltd. (1990).
Lowe et al., Drugs of the Future, 17 (9), 799-807 (1992).
Colicelli et al., Proc. Nat'l. Acad. Sci. U.S.A., 86, 3599-3603 (May, 1989).
Venter et al., Nature, 355, 632-634 (Feb., 1992).
Venter et al., Nature Genetics, 4, 256-267 (Jul., 1993).
Davis et al., Proc. Nat'l. Acad. Sci. U.S.A., 86, 3604-3608 (May, 1989).
Bolger et al., Mol. Cell. Biol., 35, 1658 (1993).
Benson Gregg C.
Elliott George G.
Larson Thomas G.
Pfizer Inc.
Richrdson Peter C.
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