Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving virus or bacteriophage
Patent
1998-04-13
2000-10-10
Brusca, John S.
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving virus or bacteriophage
435 6, 4352521, 435 912, 435471, 424 92, 4243201, C12Q 170
Patent
active
061300365
ABSTRACT:
Methods and compositions related to AIDS are disclosed. Using the methods of the present invention, candidate compounds may be screened for the ability to inhibit reverse transcriptase of human immunodeficiency virus ("HIV RT"). Active HIV RT mutants may be detected by the disclosed methods. The present invention also discloses methods for screening for compounds that inhibit HIV RT obtained from an individual patient. In another aspect, methods for testing the biological effectiveness of candidate compounds for the inhibition of HIV RT in vivo are disclosed.
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Inouye et al., "Screening For Reverse Transcriptase Inhibitors And Anti-HIV Substances," Journal Of Pharmaceutical Sciences 76(11): p. S190, Abstract No. J 07-X-01, 1987.
Kim Baek
Loeb Lawrence A.
Brusca John S.
Siu Stephen
University of Washington
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