Tumor necrosis factor antagonists and their use

Details Tumor necrosis factor antagonists and their use Tumor necrosis factor antagonists and their use

1995-05-05

1997-09-30

Patterson, Jr., Charles L.

Drug, bio-affecting and body treating compositions

Immunoglobulin, antiserum, antibody, or antibody fragment,...

Binds antigen or epitope whose amino acid sequence is...

4241411, 4241301, A61K 39395

Patent

active

056723474

ABSTRACT:
Tumor necrosis factor antagonists are administered in therapeutically effective doses to suppress inflammatory immune-potentiated events. The antagonists of this invention typically are selected from among several classes but preferably are neutralizing antibodies directed against tumor necrosis factor. The antagonists are useful in suppressing transplantation immunity and in the treatment of autoimmune diseases.

REFERENCES:
Beutler, B., et. al. (1986) Nature 320, 584-588.

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