Kit for the diagnosis of insulin dependent diabetes mellitus

Details Kit for the diagnosis of insulin dependent diabetes mellitus Kit for the diagnosis of insulin dependent diabetes mellitus

1993-03-29

1997-09-30

Cunningham, Thomas M.

Special receptacle or package

Combined or convertible

Packaged assemblage or kit

435 71, 435 79, 435 792, 530350, 530868, G01N 3353

Patent

active

056718489

ABSTRACT:
A 65 KD heat shock protein, proteins cross-reactive therewith, or antibodies thereto can be used for detecting in humans the existence of, a tendency to develop, or the initiation of a process leading to insulin dependent diabetes mellitus. Antibodies to hsp65 can be used to detect the hsp65 molecule in blood or urine. The hsp65 molecule of any species, or any other substance immunologically cross-reactive therewith, when administered with a tolerogenic carrier, can be used for the prevention or treatment of IDDM prior to development of clinical symptoms thereof.

REFERENCES:
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Atkinson, Mark A., et al., Lancet 336:1250-1251 (Nov. 17, 1990), "No role for the 65 kD heat-shock protein in diabetes".
Jones, David B., et al. Lancet 337:115 (Jan. 12, 1991), "Is there no role for heat-shock protein in diabetes?".
Kampe, Olle, et al., Lancet 336:1250 (Nov. 17, 1990), "No role for 65 kD heat-shock protein in diabetes".
Latchman, David, Nature 356;114 (Mar. 12, 1992), "No diabetes link to hsp65?".
Lydyard, Peter, et al., Immunology Today 11(7):228-9 (1990), "Heat shock proteins: immunity and immunopathology".
G.M. Bahr et al, Clin. Exp. Immunol., 74, 211-215, 1988.
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Bahr, G. M., et al., Clin. Exp. Immunol. 74:211-215 (1988), "Antibody levels to mycobacteria in relation to HLA type: evidence for non-HLA-linked high levels of antibody to the 65 KD heat shock protein of M. bovis in rheumatoid arthritis".
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S. Baekkeskov et al., "Identification of the 64K autoantigen in insulin-dependent diabetes as the GABA-synthesizing enzyme glutamic acid decarboxylase", Nature, 347: 151-156, 1990.
M. Bahr et al., "Antibody levels to mycobacteria in relation to HLA type: evidence for non-HLA-linked levels of antibody to the 65 kD heat shock protein of M.bovis in rheumatoid arthritis", Clin. Exp. Immunol., 74: 211-215, 1988.
S. Jindal et al., "Primary Structure of a Human Mitochondrial Protein Homologous to the Bacterial and Plant Chaperonins and to the 65-Kilodalton Mycobacterial Antigen", Molecular and Cellular Biology, 9(5): 2279-2283, 1989.
G. Tsoufla et al., "Raised serum IgG and IgA antibodies to mycobacterial antigens in rheumatoid arthritis", Ann. Rheum. Dis., 48: 118-123, 1989.
D. Elias et al., "Induction and therapy of autoimmune diabetes in the nonobese disbetic (NOD/Lt) Mouse by a65-kDa heat shock protein", PNAS, 87: 1990.
J. Thole et al., "Characterization, Sequence Determination, and Immunogenicity of a 64-Kilodalton Protein of Mycobacterium bovis BCG Expressed in Escherichia coli K-12", Infection and Immunity, 55(6): 1466-1475, 1987.
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Thole et al., "Characterization, Sequence Determination, and Immunogenicity of a 64-Kilodalton Protein of Mycobacterium bovis BCG Expressed Escherchia coli K-12", Infection and Immunity, 55(19):.
Minota et al., "Autoantibodies to the Heat-Shock Protein hsp90 in Systemic Lupus Erythematosus", J. Clin. Invest., 81: 106-109, 1988.
Res et al., "Synovial Fluid T Cell Reactivity Against 65 kD Heat Shock Protein of Mycobacteria in Early Chronic Arthritis", The Lancet, 478-480, 1988.
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I.R. Cohen, Ann. Rev. Immunol. 9:567-89. (1991) "Autoimmunity to chaperonins in the Pathogenesis of Arthritis and Diabetes".

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