Organic compounds -- part of the class 532-570 series – Organic compounds – Carbohydrates or derivatives
Patent
1993-04-07
1995-03-28
Rollins, John W.
Organic compounds -- part of the class 532-570 series
Organic compounds
Carbohydrates or derivatives
536 284, 536 285, 536 2851, 536 2852, 536 2853, 536 2854, 536 2855, C07H 19073
Patent
active
054018382
ABSTRACT:
A stereoselective fusion glycosylation process for prearing beta-anomer enriched 2'-deoxy-2',2'-difluoronucleotides and 2'-deoxy-2'-fluoronucleosides by reacting an alpha-anomer enriched 2-deoxy-2,2-difluorocarbohydrate or 2-deoxy-2-fluorcarbohydrate with at least a 3 molar equivalent of a nucleobase derivative at a temperature sufficient to melt the carbohydrate and nucleobase derivative.
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Boone David E.
Conrad Robert A.
Eli Lilly and Company
Persley Sidney
Rollins John W.
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