Method for the synthesis of deoxypyridinoline

Details Method for the synthesis of deoxypyridinoline Method for the synthesis of deoxypyridinoline

1997-01-13

1998-03-03

Rotman, Alan L.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

546300, C07D213127, C07D21316, C07D21320

Patent

active

057236194

ABSTRACT:
Disclosed is a method for the chemical synthesis of deoxypyridinoline (DPD). The synthesis involves the preparation of a protected 3-hydroxypyridinium starting with a N.alpha.-protected lysine and a 5,6-epoxy-2-N-protected-O-protected-(2S)-2-aminohexanoate with subsequent deprotection to provide the desired DPD.

REFERENCES:
patent: 5350855 (1994-09-01), Daniloff et al.
patent: 5502197 (1996-03-01), Daniloff et al.
patent: 5527715 (1996-06-01), Kung et al.
Auge et al, Tetrahedron Letters, vol. 37, No. 43, pp. 7715-7716 (1996), Lithium Trifluoromethanesulfonate-catalyzed . . .
Chini et al, Tetrahedron Letters, vol. 31, No. 32, pp. 4661-4664, (1990), Metal Salts as New Catalysts for Mild and Efficient . . .

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