High affinity PDGF nucleic acid ligands

Details High affinity PDGF nucleic acid ligands High affinity PDGF nucleic acid ligands

1996-03-20

1998-03-03

Zitomer, Stephanie W.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

435 6, 435 912, 536 254, 935 77, 935 78, C07H 2104, C07H 2102, C12Q 168, C12P 1934

Patent

active

057235945

ABSTRACT:
Methods are described for the identification and preparation of high-affinity nucleic acid ligands to PDGF. Included in the invention are specific ssDNA and RNA ligands to PDGF identified by the SELEX method.

REFERENCES:
patent: 4683195 (1987-07-01), Mullis et al.
patent: 4711955 (1987-12-01), Ward et al.
patent: 4828979 (1989-05-01), Klevan et al.
patent: 4935363 (1990-06-01), Brown et al.
patent: 5070010 (1991-12-01), Hsu et al.
patent: 5270163 (1993-12-01), Gold et al.
patent: 5475096 (1995-12-01), Gold et al.
patent: 5476766 (1995-12-01), Gold et al.
Johnsson, et al., Proc. Natl. Acad. Sci., U.S.A., 82:1721 (1985).
Ferns, et al., Science, 253:1129 (1991).
Herren, et al., Biochimica et Biophysica Acta, 1173:294 (1993).
Duan, et al., J. Biol. Chem., 266:413 (1991).
Teisman, et al., J. Biol. Chem., 268:9621 (1993).
Williams, et al., J. Biol. Chem., 259:5287 (1984).
Betsholtz, et al., Cell, 39:447 (1984).
Vassbotn, J. Biol. Chem., 267:15635 (1992).
Engstrom, J. Biol. Chem., 267:16581 (1992).
Buchdunger, et al., Proc. Natl. Acad. Sci., U.S.A., 92:2558 (1995).
Kovalenko, et al. Cancer Res., 54:6106 (1994).
Joyce, Gene, 82:83 (1989).
Joyce and Inoue, Nucleic Acids Research, 17:711 (1989).
Ellington, et al., Abstract of Papers presented at the 1990 meeting on RNA Processing, Cold Spring Harbor Laboratory, Cold Spring Harbor, N.Y., p. 226 (1990).
Kinzler, et al. Nucleic Acids Research, 17:3645 (1989).
Kramer, et al. J. Mol. Biol., 89:719 (1974).
Levisohn, et al. Proc. Natl. Acad. Sci., USA 63:805 (1969).
Levisohn, et al. Proc. Natl. Acad. Sci., USA60:866 (1968).
Oliphant, et al. Mol. Cell. Biol., 9:2944 (1989).
Oliphant, et al. Nucleic Acids Research, 16:7673 (1988).
Oliphant, et al. Methods in Enzymology, 155:568 (1987).
Oliphant, et al. Gene, 44:177 (1986).
Robertson, et al. Nature, 344:467 (1990).
Thiesen, et al. Nucleic Acids Research, 18:3203 (1990).
Orgel, Proc. R. Soc. Lond., B205:435 (1979).
Bass, et al. Nature, 308:820 (1984).
Carey, et al. Biochemistry, 22:2601 (1983).
Joyce, RNA: Catalysis, Splicing, Evolution, Belfort and Shub (eds.), Elsevier, Amsterdam pp. 83-87 (1989).
Kacian, et al., Proc. Natl. Acad. Sci. USA, 69:3038 (1972).
Mills, et al., Science, 180:916 (1973).
Mills, et al., Proc. Natl. Acad. Sci. USA, 58:217 (1967).
Rich, et al., Ann. Rev. Biochem, 53:791 (1984).
Robertson, et al., Nature, 344:467 (1990).
Romaniuk, et al., Biochemistry, 26:1563 (1987).
Saffhill, et al., J. Mol. Biol., 51:531 (1970).
Schimmel, et al., Cell, 58:9 (1989).
Tuerk, et al., Proc. Natl. Acad. Sci. USA, 85:1364 (1988).
Uhlenbeck, et al., J. Biomol. Structure and Dynamics, 1:539 (1983).
Witherell, et al., Biochemistry, 28:71 (1989).
Yarus, Science, 240:1751 (1988).
Matthew, et al., Analytical Biochemistry, 169:1 (1988).
Andrake, et al., Proc. Natl. Acad. Sci. USA, 85:7924 (1988).
Cohen, et al., Proc. Natl. Acad. Sci. USA. 63:458 (1969).
Maniatis, et al., Molec. Cloning: A Laboratory Manual, Cold Spring Harbor, NY, p. 118 (1982).
Muesing, et al., Nature, 313:450 (1985).
Maniatis, et al., Science, 236:1237 (1987).
Watson, et al., Molec. Biol. of the Gene, Benjamin/Cummings Publishing Co., pp. 267, 295, 323, 361, 394, 396, 397, 405 (1987).
Ma, et al., Cell, 51:113 (1987).
Min, et al., Nucl. Acids Res., 16:5075 (1988).
Ou, et al., Science, 239:295 (Jan. 15, 1988).
Lestienne, et al., Biochimie, 65:49 (1983).
Ellington, et al., Nature, 346:818 (1990).
Bock, et al., Nature, 355:564 (Feb. 6, 1992).
Stein, et al., Science, 261:1004 (Aug. 20, 1993).
Miele, et al., J. Mol. Biol., 171:281-295.
Tuerk, et al., Science, 249:505 (1990).

Affiliated with

Also associated with

Rating

High affinity PDGF nucleic acid ligands does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with High affinity PDGF nucleic acid ligands, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and High affinity PDGF nucleic acid ligands will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-2248874