Synthetic resins or natural rubbers -- part of the class 520 ser – Synthetic resins – Polymers from only ethylenic monomers or processes of...
Patent
1997-03-27
1998-03-03
Schofer, Joseph L.
Synthetic resins or natural rubbers -- part of the class 520 ser
Synthetic resins
Polymers from only ethylenic monomers or processes of...
560222, C08F13002, C07C 6960, C07F 910
Patent
active
057235589
DESCRIPTION:
BRIEF SUMMARY
FIELD OF THE TECHNIQUE
The present invention relates to a novel and useful fumaric acid derivative having a phospholipid-like molecular structure and to a polymer obtained therefrom, especially such a polymer that can be utilized as starting material for medical materials, biosensors, cosmetics and so on.
BACKGROUND OF THE TECHNIQUE
It has been made clear that the body of an organism contains various phospholipids which play each an important role for maintaining its life. For example, phospholipids have an intimate correlation with various metabolic processes in living organisms and, in addition, they play very important roles in the energy sources of brain tissues, in the transference and absorption of fat, in the coagulation of blood and in the dietetic sense of tastes for foods. Thus, phospholipids are components of cytoplasm, such as cell wall etc., and exhibit many functions in the life maintenance of totality of an organism.
On the other hand, many polymeric substances have found their use in the, field of medical materials and, for example, in the field of surgery, medical materials including artificial organs made of medical polymeric substances are in practical use. Artificial organs are substituted for or reconstruct lost biological functions, so that biological adaptability in organisms including, for example, anticarcinogenicity and anticorrosiveness, are required. When a biological material constituted of a polymeric substance without bioadaptability is used, problems may occur such as follows. Thus, when a medical material is brought into contact with, for example, blood etc., within a living body by a surgical operation, the surfaces of the medical material will soon become covered with a protein film and bring forth thereafter foreign body reactions on a cellular level with, for example, blood platelet, lymphocyte and macrophage, whereby a thrombus formation, an inflammation or a bulimia may occur. Therefore, a medical material requires a property for difficultly adhering proteins thereon, i.e., anti-protein-adhesion.
As a polymeric substance for medical material, polymer of methyl methacrylate is known. This polymethyl methacrylate is superior in the transparency and is used for a starting material of hard contact lens. Contact lenses made of polymethyl methacrylate are apt to suffer from adhesion of proteins, so that rinses of them should not be neglected. Also polymers of fumaric acid esters as well as of fumaramide are known for the polymeric substance of medical materials. While these polymers are superior in the transparency and in the permeability of gases such as oxygen gas etc., they are desired to be improved for their anti-protein-adhesion and bio-compatibility.
An object of the present invention is to provide a novel and useful fumaric acid derivative which can be polymerized easily and can produce by the polymerization a polymer which is superior in the anti-protein-adhesion, in the antithromboticity and in the bio-compatibility and has, in addition thereto, a high hardness, high transparency and high gas permeability.
Another object of the present invention is to provide a polymer of the above-mentioned fumaric acid derivative, which is superior in the anti-protein-adhesion, in the antithromboticity and in the biocompatibility and has, in addition thereto, a high hardness, high transparency and high gas permeability.
DISCLOSURE OF THE INVENTION
The fumaric acid derivative according to the present invention is a compound represented by the following general formula (1): ##STR3## in which R.sup.1 represents an alkyl group having 1-6 carbon atoms and A denotes a radical of ##STR4## wherein R.sup.2 and R.sup.3 represent each an alkyl group having 1-4 carbon atoms and may be identical with or different from each other, R.sup.4 denotes an alkyl group having 1-6 carbon atoms or a benzyl group and m and n denote each an integer of 1-6.
The polymer according to the present invention is a polymer of a fumaric acid derivative including the structural unit represented by the follo
REFERENCES:
patent: 4707306 (1987-11-01), Leighton et al.
Hayashi Akio
Kadoma Yoshihito
Oishi Tsutomu
Cheng Wu C.
NOF Corporation
Schofer Joseph L.
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