Peptide library and screening systems

Details Peptide library and screening systems Peptide library and screening systems

1990-06-20

1998-03-03

Knode, Marian C.

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving virus or bacteriophage

435 6, 935 80, 935 81, C12Q 170, C12Q 160, C12N 1564

Patent

active

057232865

ABSTRACT:
Peptides which bind to selected receptor molecules are identified by screening libraries which encode a random or controlled collection of amino acids. Peptides encoded by the libraries are expressed as fusion proteins of bacteriophage coat proteins, and bacteriophage particles are then screened against the receptors of interest. Peptides having a wide variety of uses, such as therapeutic or diagnostic reagents, may thus be identified without any prior information on the structure of the expected ligand or receptor molecule.

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